NAD+ is poorly absorbed when taken orally, so one of the best ways to replenish it is intravenous therapy. Clinical studies show that continuous supplementation with NAD+ precursors can blunt its effects over time, so the intermittent nature of intravenous therapy may strengthen its benefits. 

• Boosting NAD+ may address several underlying causes of aging. Research demonstrates that NAD+ and its precursors can:

• Restore cellular energy production, which falls with age. This also improved overall cellular health.

• Prevent development of “aged” cells, reducing inflammation as a result.

• Maintain cells’ ability to divide, a requirement for tissue maintenance and repair.

• Protect stem cell populations, which your body needs to fix everyday wear and tear.

• Regulate the development of stem cells into mature cells. For example, NAD+ precursors increase transformation into bone cells, and prevent fat cell development.

• Improve blood sugar control. Much of NAD’s anti-aging effects are controlled by its interactions with the sirtuin genes. Their activity is essential for healthy energy metabolism, which becomes more dysregulated with age.

Clinical studies show several key benefits of NAD+: 

• Improved energy

• Increased muscle mass, especially when combined with regular exercise

• An increase in bone density

• Improved cardio performance in runners

• Better insulin sensitivity.

People who have been struggling with the effects of aging or chronic illness (or both!) stand to benefit the most from NAD+ restoration. Fatigue disorders, blood sugar dysregulation, or muscle loss from long-term inactivity are some potential indications for NAD+ therapy. Partying hard over the holidays or your vacation may call for replenishing NAD+ too, thanks to the role of NAD+ in energy metabolism. 

Additionally, the performance-enhancing effects of NAD+ may make it helpful if you are just starting to work out or practice sports. NAD+ can benefit more experienced athletes who want to recover faster after workouts, heal from injuries faster, or improve their overall performance. 

References

https://www.science.org/doi/10.1126/science.aaf2693?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed 

https://www.nmn.com/news/nmn-restores-stem-cells-bone-tissue-activating-nap1l2-protein 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036060/